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GLP-1 Agonists: Beyond Blood Sugar Control and Weight Loss
What are GLP-1 agonists?
GLP-1 agonists, also known as glucagon-like peptide-1 receptor agonists, are a class of medications primarily used to manage blood sugar levels in people with Type 2 diabetes. These injectable medications work by mimicking the effects of the naturally occurring GLP-1 hormone. Here’s how they work:
- Insulin Release: GLP-1 triggers insulin release from the pancreas, helping lower blood sugar levels.
- Glucagon Inhibition: It blocks glucagon secretion, preventing excess glucose from entering the bloodstream.
- Slower Stomach Emptying: GLP-1 slows down digestion, reducing the release of glucose from food.
- Increased Satiety: GLP-1 affects hunger and fullness centers in the brain, making you feel more satisfied after eating.
Benefits Beyond Blood Sugar and Weight
In addition to blood sugar control and weight loss, GLP-1 agonists offer other potential benefits:
- Lowering Blood Pressure: Some studies suggest that GLP-1 agonists may help reduce blood pressure.
- Improving Lipid Disorders: These medications may positively impact lipid profiles.
- Fatty Liver Disease: GLP-1 agonists could improve fatty liver disease.
- Reducing Heart and Kidney Disease Risk: Research indicates a potential protective effect against heart disease and kidney disease. GLP-1 impacts cardiac contractility, myocardial glucose uptake, oxidative stress and mitochondrial homeostasis. GLP-1 agonists are associated with a 20% reduced risk of major cardiovascular events compared to other diabetes drugs.
- Delaying Diabetes-Related Nephropathy: GLP-1 agonists may slow the progression of kidney complications related to diabetes.
Remember, GLP-1 agonists complement lifestyle changes and other treatments for diabetes and obesity. Consult your healthcare provider to determine if they’re right for you!
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